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Teresa M. Gunn, PhD

Professor

Gene Editing and Mutant Mouse Assessment (GEMMA) Core Facility Director

Research Interests

Mouse models of disease.

Molecular mechanisms of neurodevelopment and neurodegeneration.

Mosmo-MEGF8-Mahogunin Ring Finger-1 (MMM) complex in left-right patterning and congenital heart disease.

SOX10 regulation of myelination and CNS development.

  • Education

    McGill University, BS, Biology - Human Genetics (1990)

    University of British Columbia, PhD, Genetics (1996)

    Positions

    1995-2001 | Postdoctoral Fellowship, Stanford University, Palo Alto, CA

    2001-2006 | Assistant Professor, Dept of Biomedical Sciences, Cornell University, Ithaca, NY

    2006-2009 | Robert Hovey Udall Assistant Professor, Dept of Biomedical Sciences, Cornell University, Ithaca, NY

    2009-2021 | Associate Professor, McLaughlin Research Institute

    2009-Present | Director, McLaughlin Research Institute Transgenic Facility

    2021-Present | Professor, McLaughlin Research Institute

    2023-Present | University College of Osteopathic Medicine, Professor, Touro University College of Osteopathic Medicine, Montana

    2024-Present | Director, Gene Editing and Mutant Mouse Assessment (GEMMA) Core, McLaughlin Research Institute Center for Integrated Biomedical and Rural Health Research

    2024-Present | Adjunct Professor, Touro University College of Osteopathic Medicine, Middletown, NY

    Professional Activities

    1995-present | Member, International Mammalian Genome Society (IMGS); Nominations and Elections Committee (2006-2008); Secretariat (2010-2012 and 2023-2026); President Elect/President/Past President (2012-2018)

    2023-present | Member, International Transgenic Technology Society (ITTS)

    2023-2027 | Member, Genetics of Health and Disease NIH study section

    2023-2026 | Mouse Genome Database (MGD) Scientific Advisory Board

  • View all of Dr. Gunn’s publications at:

    http://www.ncbi.nlm.nih.gov/sites/myncbi/1LSXfHps6fhA1/bibliography/40104746/public/?direction=ascending&sort=date

    Klingeborn, M, Arora, V, Chung, C, Donchenko, P, Wright, RN, Reese, ED, Gunn, TM (2025) Desmosome and Hemidesmosome Release via Exosomes from Retinal Pigmented Epithelium – A Precursor to Epithelial-Mesenchymal Transition in Early AMD? Curr Eye Res, 11:1-10. PMID: 40070018.

    Elazar, D, Alvarez*, N, Drobeck*, S, Gunn, TM. SLC1A4 and Serine Homeostasis: Implications for Neurodevelopmental and Neurodegenerative Disorders. Int J Mol Sci 26(5), 2104. Special issue on Neurodegenerative Disease: From Molecular Basis to Therapy, 3rd ed. PMID: 40076728. *Authors contributed equally.

    Silvius, D, Hurley, E, Poitelon, Y, Wagner, KU, Feltri, ML, Gunn, TM (2025) Schwann cell deletion of Tumor Susceptibility Gene 101 (Tsg101) in mice results in severe peripheral neuropathy. microPublication Biology. PMID: 40061016.

    Ratz-Mitchem ML, Leary G, Grindeland A, Silvius D, Guter J, Kavanaugh MP, Gunn TM. Generation and characterization of a knock-in mouse model for Spastic Tetraplegia, Thin Corpus Callosum, and Progressive Microcephaly (SPATCCM). (2023) Mamm Genome 34(4):572-585. PMID: 37642681.

    Barratt KS, Dai Y, Miller DR, Gunn TM, Siracusa LD (2023) 35th International Mammalian Genome Conference: meeting overview. Mamm Genome 34(3):449-452. PMID: 36867211.

    Kong JH, Young CB, Pusapati GV, Espinoza FH, Patel CB, Beckert F, Ho S, Patel BB, Gabriel GC, Aravind L, Bazan JF, Gunn TM, Lo CW, Rohatgi R (2021) Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength. Development 148(19). PMID: 34486668.

    Kong, JH, Young, CB, Pusapati, GV, Patel, CB, Ho, S, Krishnan, A, Lin, J-HI, Devine, W, Moreau de Bellaing, A, Athni, TS, Aravind, L, Gunn, TM, Lo, CW, Rohatgi, R (2020) A Membrane-Tethered Ubiquitination Pathway Regulates Hedgehog Signaling and Heart Development. Dev Cell 55(4): 432-449. PMID: 32966817.

    Gunn, TM, Silvius, D, Lester, A and Gibbs, B (2019) Chronic and age-dependent effects of the spongiform neurodegeneration-associated MGRN1 E3 ubiquitin ligase on mitochondrial homeostasis. Mamm Genome 30(5-6): 151-165. PMID: 31089807.

    Walker WP, Oehler A, Edinger AL, Wagner KU, Gunn TM. (2016) Oligodendroglial deletion of ESCRT-I component TSG101 causes spongiform encephalopathy. Biol Cell 2016 Jul 13. doi: 10.1111/boc.201600014. PMID:27406702.

    Anderson, SR, Lee, I, Ebeling, C, Stephenson, DA, Schweitzer, KM, Baxter, D,Moon, TM, LaPierre, S, Jaques, B, Silvius, D, Wegner, M, Hood, LE, Carlson, G,Gunn, TM (2015) Disrupted SOX10 function causes spongiform neurodegeneration in gray tremor mice. Mamm Genome 26(1-2):80-93. PMID:25399070.

    Gunn, TM and Carlson, GA (2013) RML prions act through Mahogunin and Attractin-independent pathways. Prion 7(4): 267-71. PMID: 23787699

    Silvius, D, Pitstick, R, Ahn, M, Meishery, D, Oehler, A, Barsh, GS, DeArmond, SJ,Carlson, GA, Gunn, TM (2013) Levels of the Mahogunin Ring Finger 1 E3 ubiquitin ligase do not influence prion disease. PLOS-One 8(1): e55575. PMID:23383230

    Gunn, TM, Silvius, D, Bagher, P, Sun, K, Walker, KK (2013) MGRN1-dependentpigment-type switching requires its ubiquitination activity but not its interaction with TSG101 or NEDD4. Pigment Cell Melanoma Res. 2013 26(2): 263-68. PMID:23253940