McLaughlin Institute

George A. Carlson, PhD

Director and Professor

george carlson

Laboratory Members

Postdoctoral Fellows
Brenda Canine, Ph.D.
Andrea Grindeland, DVM

Administrative/Senior Research Assistant
Jill O’Moore

Senior Research Assistant
Rose Pitstick

 

Education

University of Pennsylvania, AB, Biochemistry, 1969

Tufts University, PhD, Physiology, 1976 

 

Positions

1969-1970  Instructor of Biology. Berkshire School, Sheffield, MA

1973-1974  Lecturer in Physiology. Tufts-Boston School of Occupational Therapy, Boston, MA

1970-1975 Predoctoral Research Fellow. Dr. G. Terres, Tufts University School of Medicine, Boston, MA

1975-1977  Leukemia Society Postdoctoral Fellow. Dr. T.G. Wegmann, Department of Immunology, University of Alberta, Edmonton, Alberta, Canada (Immunogenetics)

1977-1980  Assistant Professor of Immunology. University of Alberta, Edmonton, Alberta, Canada

1980-1985  Associate Staff Scientist. The Jackson Laboratory, Bar Harbor, ME

1985-1988  Staff Scientist (Associate Professor). The Jackson Laboratory, Bar Harbor, ME

1988-2008  Adjunct Professor of Microbiology. Montana State University, Bozeman, MT

2008-present  Adjunct Professor of Cell Biology and Neuroscience. Montana State University, Bozeman, MT

1993-present  Adjunct Professor of Biological Sciences/Pharm. Sci. University of Montana, Missoula, MT

1993-1997  Advisor/Consultant. Millennium Pharmaceuticals, Inc., Cambridge, MA

1988-present  Director and Professor. McLaughlin Research Institute, Great Falls, MT

 

Major Areas of Research

Identification of early biomarkers for neurodegenerative disease detection.

Identification of common pathways involved in neurodegenerative diseases.

 

Description of Research

The underlying theme of Dr. Carlson’s research is the application of formal and molecular mouse genetics to advance the understanding of susceptibility to neurodegenerative diseases. George is now applying his expertise in mouse genetics to a systems analysis of prion disease in collaboration with Dr. Lee Hood at the Institute for Systems Biology in Seattle, Washington. Dr. Carlson and his colleagues also developed what may be the first genetically tractable in vitro model for prion disease by successfully infecting CNS stem cell containing neurosphere cultures. He is now using neurosphere cultures to model biochemical events in mouse models for frontotemporal dementia and other prion-like neurodegenerative disorders, several of which he was involved in creating.

 

Current Publications

Pooler AM, Polydero M, Maury EA, Nicholls SB, Reddy SM, Wegmann S, William C, Saqran L, Cagsal-Getkin O, Pitstick R, Beier DR, Carlson GA, Spires-Jones TL, Hyman BT. Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer’s disease. Acta Neuropatholigica Communications. 2015, 3;14

Anderson SR, Lee I, Ebeling C, Stephenson DA, Schweitzer KM, Baxter D, Moon TM, LaPierre S, Jaques B, Silvius D, Wegner M, Hood LE, Carlson G, Gunn TM. Disrupted SOX10 function causes spongiform neurodegeneration in gray tremor mice. Mamm Genome. 2014, Nov 16. PMID: 25399070

Helmering J, Juan T, Li CM, Chhoa M, Baron W, Gyuris T, Richards WG, Turk JR, Lawrence J, Cosgrove PA, Busby J, Kim KW, Kaufman SA, Cummings C, Carlson G, Véniant MM, Lloyd DJ.  A mutation in Ampd2 is associated with nephrotic syndrome and hypercholesterolemia in mice. Lipids Health Dis. 2014, Oct 31;13(1):167. PMID: 25361754 PMC4232700

Ghate PS, Sidhar H, Carlson GA, Giri R. Development of a novel cellular model of Alzheimer’s disease utilizing neurosphere cultures derived from B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J embryonic mouse brain. SpringerPlus. 2014, Mar 26 3:161. PMID: 25140287

Park L, Koizumi K, El Jamal S, Zhou P, Previti ML, Van Nostrand WE, Carlson G, Iadecola C. Age-dependent neurovascular dysfunction and damage in a mouse model of cerebral amyloid angiopathy. Stroke. 2014, Jun;45(6):1815-21. PMID: 24781082

Spires-Jones TL, Friedman T, Pitstick R, Polydoro M, Roe A, Carlson GA, Hyman BT. Methylene blue does not reverse existing neurofibrillary tangle pathology in the rTg4510 mouse model of tauopathy. Neuroscience Letter. 2014, Mar 6;562:63-8. PMID: 24462887

Polydoro M, Dzhala VI, Pooler AM, Nicholls SB, McKinney AP, Sanchez L, Pitstick R, Carlson GA, Staley KJ, Spires-Jones TL, Hyman BT. Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer’s disease model. Acta Neuropathol. 2014, Feb;127(2):257-70 PMID: 24271788

Graham DL, Gray AJ, Joyce JA, Yu D, O’Moore J, Carlson GA, Shearman MS, Dellovade TL, Hering H. Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy. Neuropharmacology. 2013, Dec 8;79:307-313. PMID: 24326295

Pooler AM, Polydoro M, Wegmann SK, Pitstick R, Kay KR, Sanchez L, Carlson GA,    Gomez-Isla T, Albers MW, Spires-Jones TL, Hyman BT. Tau-Amyloid interactions in the rTgTauEC model of early Alzheimer’s disease suggest amyloid-induced disruption of axonal projections and exacerbated axonal pathology. J Comp Neurology. 2013, Dec 15;521(18):4236-48 PMID: 23839581

Kopeikina KJ, Wegmann S, Pitstick R, Carlson GA, Bacskai BJ, Betensky RA, Hyman BT, Spires-Jones TL. Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy. PLoS One. 2013, Nov 20;8(11):e80834. PMID: 24278327

George L, Chaverra M, Wolfe L, Thorne J, Close-Davis M, Eibs A, Riojas V, Grindeland A, Orr M, Carlson G, Lefcort F. Familial Dysautonomia model reveals Ikbkap is required to prevent apoptosis of pax3+ progenitors and peripheral neurons. Proc Natl Acad Sci (USA). 2013, Nov 12;110(46):18698-703. PMID: 24173031 PMC3831979

Cameron A, Giacomozzi B, Joyce J, Gray A, Graham DL, Ousson S, Neny M, Beher D, Carlson GA, O’Moore J, Shearman M, Hering H. Generation and characterization of a rabbit monoclonal antibody site-specific for tau O-GlcNAcylated at serine 400. FEBS Lett. 2013, Nov 15;587(22):3722-8. PMID: 24113653

Polydoro M, de Calignon A, Suarez-Calvet M, Sanchez L, Kay KR, Nicholls SB, Roe AD, Pitstick R, Carlson GA, Gomez-Isla T, Spires-Jones TL, Hyman BT. Reversal of Neurofibrillary Tangles and Tau-Associated Phenotype in the rTgTauEC Model of Early Alzheimer’s. J Neurosci. 2013, Aug; 33(33):13300-11. PMID: 23946388

Gunn TM, Carlson GA. RML prions act through Mahogunin and Attractin-independent pathways. Prion. 2013 May 31;7(4). PMID: 23787699

Silvius D, Pitstick R, Ahn M, Meishery D, Oehler A, Barsh GS, DeArmond SJ, Carlson GA, Gunn TM. Levels of the mahogunin ring finger 1 E3 ubiquitin ligase do not Influence prion disease. PLoS ONE. 2013, 8(1): e55575. doi: 10.1371/journal.pone.0055575. PMCID: PMC3559536

Kopeikina KJ, Polydoro M, Tai HC, Carlson GA, Pitstick R, Hyman BT, Spires-Jones TL. Synaptic alterations in the rTg4510 mouse model of tauopathy. J Comp Neurol. 2013, Apr 15;521(6):1334-53. PMID: 23047530

Park L, Zhou J, Zhou P, Pitstick R, El Jamal S, Younkin L, Pierce J, Arreguin A, Anrather J, Younkin SG, Carlson GA, McEwen BS, IIadecola C. The innate immunity receptor CD36 promotes cerebral amyloid angiopathy. Proc Natl Acad Sci (USA). 2013, Feb 19;110(8):3089-94. PMCID: PMC3581946

Park L, Zhou P, Koizumi K, El Jamal S, Previti ML, Van Nostrand WE, Carlson G, Ladecola C. Brain and circulating levels of aß1-40 differentially contribute to vasomotor dysfunction in the mouse brain. Stroke. 2013, Jan;44(1):198-204. PMID: 23204056

Price N, Eldeman L, Lee I, Yoo H, Hwang D, Carlson G, Galas D, Heath J, Hood L. Systems Biology and Systems Medicine. In: Genomic and Personalized Medicine. 2013. G.S. Ginsburg and H.F. Willard Editors. Academic Press, UK, USA. Vol 1, Section 1, Chapter 5, pp 60-72.

Tara Leigh Spires-Jones, Leora M Fox, Anete Rozkalne, Rose Pitstick, George A. Carlson, Aleksey G. Kazantsev. Inhibition of sirtuin 2 with sulfobenzoic acid derivative AK1 is non-toxic and potentially neuroprotective in a mouse model of frontotemporal dementia. Frontiers in Experimental Pharmacology and Drug Discovery. In Press. PMID: 22416232

De Calignon A, Polydoro M, Suarez-Calvert M, William C, Adamowicz DH, Kopeikina KJ, Pitstick R, Sahara N, Ashe KH, Carlson GA, Spires-Jones TL, Hyman BT. Propagation of tau pathology in a model of early Alzheimer’s disease. Neuron. 2012 Feb 23; 73(4): 685-697. PMID: 22365544

Westaway D, Genovesi S, Daude N, Brown R, Lau A, Lee I, Mays CE, Coomaraswamy J, Canine B, Pitstick R, Herbst A, Yang J, Ko KWS, Schmitt-Ulms G, DeArmond S, McKenzie D, Hood L, Carlson GA. Down-regulation of Shadoo in prion infections traces a pre-clinical event inversely related to PrPSc accumulation. PloS Pathogens. 2011 Nov; 7(11):1-18. PMID: 22114562

Kopeikina KJ, Carlson GA, Pitstick R, Ludvigson AE, Luebke JI, Koffie RM, Frosch MP, Hyman BT, Spires-Jones TL. Tau Accumulation Causes Mitochondrial Distribution Deficits in Neurons in a Mouse Model of Tauopathy and in Human AD Brain. Am J Pathol. 2011 Oct; 179(4):2071-2082 PMID: 21854751

Lan X, Kiyota T, Hanamsagar R, Huang Y, Andrews S, Peng H, Zheng JC, Swindells S, Carlson GA, Ikezu T. The Effect of HIV Protease Inhibitors on Amyloid-β Peptide Degradation and Synthesis in Human Cells and Alzheimer’s Disease Animal Model. J Neuroimmune Pharmacol. 2011 Aug 9. [Epub ahead of print] PMID: 21826404

Fox LM, William CM, Adamowicz DH, Pitstick R, Carlson GA, Spires-Jones TL, Hyman BT. Soluble tau species, not neurofibrillary aggregates, disrupt neural system integration in a tau transgenic model. J Neuropathol Exp Neurol. 2011 Jul;70(7):588-95. PMID: 21666499

Park L, Wang G, Zhou P, Zhou J, Pitstick R, Previti M, Younkin L, Younkin S, Van Nostrand W, Cho S, Anrather J, Carlson G, Iadecola C. Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-beta. Proc Natl Acad Sci. (USA) 2011, 108(12): 5063-68. PMID: 21383152

Hnasko R, Serban AV, Carlson G, Prusiner SB, Stanker LH. Generation of antisera to purified prions in lipid rafts.  Prion. 2010 4(2): 94-104  Erratum to:  Generation of antisera to purified prions in lipid rafts. Prion. 2011 Jul 1;5(3). ). PMID; 21844667

Hoover B, Reed M, Su J, Penrod R, Kotilinek L, Gtant M, Pitstick R, Carlson GA, Lanier L, Yuan L, Ashe K, Liao D.  Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration.  Neuron.  2010, 68:1067-1081. PMID: 21172610

The Prion Disease Database (PDDB) is a public database that supports the prion disease research community by collecting, integrating, and presenting data from public sources and collaborating laboratories. The PDDB was originally created by the Institute for Systems Biology and the McLaughlin Research Institute, which have researched prion disease using a systems biology approach.

  • Recent Posts
  • Archives
  • Zoom in Regular Zoom out
 
Support MRI FACEBOOK Charity Navigator

© 2012 McLaughlin Research Institute of Biomedical Sciences - All Rights Reserved
Site Designed and Developed by Shortgrass Web Development