McLaughlin Institute

Ed Schmidt, Ph.D.

Affiliate Professor

Phone:  (406) 994-6375
Email Ed Schmidt

Education

University of Montana, BS, Microbiology, Cell Biology, and Zoology, 1985
Oregon State University, PhD, Biochemistry and Biophysics, 1990

Positions

1991-1996 Postdoctoral Research Assistant, Dept of Molecular Biology, Univesity of Geneva, Switzerland
1997-1999 Postdoctoral Research Assistant/Research Assistant Professor. Department of Human Genetics, University of Utah.
1999-2005 Assistant Professor. Veterinary Molecular Biology, Montana State University.
2005-Present Adjunct Faculty. Center for Reproductive Biology, Washington State University.
2005-2009 Affiliate Faculty. Biochemistry Department, University of Washington.
2010-2014 Associate Professor. Department of Immunology & Infectious Disease
2014-Present Professor. Department of Microbiology & Immunology (formerly “Immunology & Infectious Disease” or “Veterinary Molecular Biology”), Montana State University
2015-2020 Appointed, Fulbright Specialists Roster, Institute of International Education (IIE), Council for International Exchange of Scholars (CIES), US Department of State (5-year term)

 

Research Summary

The Schmidt Lab studies intricate genetic mechanisms that function in the development and maintenance of complex organisms, like ours elves. Our work is based on analyses of mouse lines we produce with targeted mutations. The biological processes we are studying include early embryonic patterning and development, placental development, metabolism, liver regeneration, redox homeostasis, redox signaling, stress responses, stem cell biology, immune cell functions, and the maternal/fetal immune interaction. Using our novel mouse models, we recently identified the first known constitutive NADPH-independent disulfide reductase pathway, which is able to sustain cell survival and homeostasis in mammalian liver under conditions that disrupt all canonical NADPH-dependent systems.

 

Selected Publications

Miller CG, Holmgren A, Arnér ESJ, Schmidt EE. NADPH-dependent and -independent disulfide reductase systems. Free Rad Biol Med. 2018; In press

Dagnell M, Schmidt EE, Arnér ESJ. The A to Z of modulated cell patterning by mammalian thioredoxin reductases. Free Rad Biol Med. 2018; 115:484-496.

Fan H, Paiboonrungruan C, Zhang X, Prigge JR, Schmidt EE, Sun Z, Chen X. Nrf2 regulates cellular behaviors and Notch signaling in oral squamous cell carcinoma cells. Biochem Biophys Res Comm. 2017; 493(1):833-839.

Romero R, Sayin VI, Davidson SM, Bauer MR, Singh SX, LeBoeuf SE, Karakousi TR, Ellis DC, Bhutkar A, Sánchez-Rivera FJ, Subbaraj L, Martinez B, Bronson RT, Prigge JR, Schmidt EE, Thomas CJ, Goparaju C, Davies A, Dolgalev I, Heguy A, Allaj V, Poirier JT, Moreira AL, Rudin CM, Pass HI, Vander Heiden MG, Jacks T, Papagiannakopoulos T. Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis. Nature Med. 2017; 23(11):1362-1368.

Prigge JR, Coppo L, Martin SS, Ogata F, Miller CG, Bruschwein MD, Orlicky DJ, Shearn CT, Kundert JA, Lytchier J, Herr AE, Mattsson Å, Taylor MP, Gustafsson TN, Arnér ESJ, Holmgren A, Schmidt EE. Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase. Cell Reports. 2017; 19(13):2771-2781.

Gladyshev VN, Arnér ES, Berry MJ, Brigelius-Flohé R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Flohé L, Green FR, Guigó R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, Köhrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonović M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y. Selenoprotein Gene Nomenclature. J Biol Chem. 2016; 291(46):24036-24040.

Lan A, Li W, Liu Y, Xiong Z, Zhang X, Zhou S, Palko O, Chen H, Kapita M, Prigge JR, Schmidt EE, Chen X, Sun Z, Chen XL. Chemoprevention of oxidative stress-associated oral carcinogenesis by sulforaphane depends on NRF2 and the isothiocyanate moiety. Oncotarget. 2016; 7(33):53502-53514.

Chio IIC, Jafarnejad SM, Ponz-Sarvise M, Park Y, Rivera K, Palm W, Wilson J, Sangar V, Hao Y, Öhlund D, Wright K, Filippini D, Lee EJ, Da Silva B, Schoepfer C, Wilkinson JE, Buscaglia JM, DeNicola GM, Tiriac H, Hammell M, Crawford HC, Schmidt EE, Thompson CB, Pappin DJ, Sonenberg N, Tuveson DA. NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer. Cell. 2016; 166(4):963-976.

Shepardson KM, Larson K, Morton RV, Prigge JR, Schmidt EE, Huber VC, Rynda-Apple A. Differential Type I Interferon Signaling Is a Master Regulator of Susceptibility to Post-influenza Bacterial Super-infection. mBio. 2016; 7(3).

Dóka É, Pader I, Bíró A, Johansson K, Cheng Q, Ballagó K, Prigge JR, Pastor-Flores D, Dick TP, Schmidt EE, Arnér ES, Nagy P. A novel persulfide detection method reveals protein persulfide- and polysulfide-reducing functions of thioredoxin and glutathione systems. Science Adv. 2016; 2(1):e1500968.

Prigge JR, Hoyt TR, Dobrinen E, Capecchi MR, Schmidt EE, Meissner N. Type I IFNs Act upon Hematopoietic Progenitors To Protect and Maintain Hematopoiesis during Pneumocystis Lung Infection in Mice. J Immunol. 2015; 195(11):5347-57.

Cebula M, Schmidt EE, Arnér ES. TrxR1 as a potent regulator of the Nrf2-Keap1 response system. Antiox Redox Sig. 2015; 23(10):823-53.

Schmidt EE. Interplay between cytosolic disulfide reductase systems and the Nrf2/Keap1 pathway. Biochem Soc Trans. 2015; 43(4):632-8.

Eriksson S, Prigge JR, Talago EA, Arnér ES, Schmidt EE. Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver. Nature Comm. 2015; 6:6479.

Mailhiot SE, Zignego DL, Prigge JR, Wardwell ER, Schmidt EE, June RK. Non-Invasive Quantification of Cartilage Using a Novel In Vivo Bioluminescent Reporter Mouse. PLoS ONE. 2015; 10(7):e0130564.

Chen H, Fu J, Chen H, Hu Y, Soroka DN, Prigge JR, Schmidt EE, Yan F, Major MB, Chen X, Sang S. Ginger compound [6]-shogaol and its cysteine-conjugated metabolite (M2) activate Nrf2 in colon epithelial cells in vitro and in vivo. Chem Res Toxicol. 2014; 27(9):1575-85.

Sonsteng KM, Prigge JR, Talago EA, June RK, Schmidt EE. Hydrodynamic delivery of Cre protein to lineage-mark or time-stamp mouse hepatocytes in situ. PLoS One. 2014 March 13:9(3):e91219.

 Gorrini C, Gang BP, Bassi C, Wakeham A, Baniasadi SP, Hao Z, Li WY, Cescon DW, Li YT, Molyneux S, Penrod N, Lupien M, Schmidt EE, Stambolic V, Gauthier ML, Mak TW. Estrogen controls the survival of BRCA1-deficient cells via a PI3K-NRF2-regulated pathway. Proc. Natl. Acad Sci USA. 2014 Mar 25:111(12):4472-7.

Prigge JR, Wiley JA, Talago EA, Young EM, Johns LL, Kundert JA, Sonsteng KM, Halfor WP, Capecchi MR, and Schmidt EE: Nuclear double-flourescent reporter for in vivo and ex vivo analyses of biological transitions in mouse nuclei. 2013, Mamm Genome, 24:389-99.

Iverson SV, Eriksson S, Xu J, Prigge JR, Talago EA, Meade TA, Meade ES, Capecchi MR, Arnér ESJ, and Schmidt, EE: A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage, and acetaminophen susceptibility. 2013, Free Rad Biol 63:369-80.

Huebner AJ, Dai D, Morasso M, Schmidt EE, Schäfer M, Werner S, Roop DR. Amniotic fluid activiates the Nrf2/Keap 1 pathway to repair an epidermal barrier defect in utero. Dev Cell.  2012, 23(6):1238-46.

Locy ML, Rogers LK, Prigge JR, Schmidt EE, Arnér E, Tipple TE. Tioredoxin reductase inhibition elicits Nrf2-mediated responses in clara cells: implications for oxidant-induced lung injury. Antioxid. Redox Signal. 2012. 17(10) 1407-16.

Prigge JR, Eriksson S, Iverson SV, Meade T, Capecchi MR, Arnér ESJ, and Schmidt EE: Hapatocyte replication in growing liver requires either flutathione or a single allele of txnrdl. Free Rad. Biol. Med., 2012, 52:803-812.

Iverson SV, Comstock CM, Kundert JA, and Schmidt EE: Contributions of new hepatocyte lineages to liver growth, maintenance, and regeneration in mice. Hepatology 2011, 64(2)655-663.

Rollins MF, DM van der Heide, et al. (2010). “Hepatocytes lacking thioredoxin reductase 1 have normal replicate potential during development and regeneration.” J Cell Sci 123(Pt 14):2402-2412.

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